Study Questions Benefits of Alzheimer’s Drugs

A large-scale analysis of clinical trials suggests that anti-amyloid drugs for Alzheimer’s disease offer limited clinical benefit, according to the Guardian. A Cochrane review found only minimal improvements in cognitive function and dementia severity over 18 months, with little measurable impact on daily functioning.

The study analysed 17 trials involving more than 20,000 patients and assessed seven drugs designed to remove amyloid plaques from the brain. It also identified a higher incidence of side effects, including brain swelling and bleeding.

Some experts have criticised the methodology, arguing that the analysis combines older, unsuccessful drugs with newer treatments. They warn this may distort the overall findings.

Regulators have approved several newer drugs that show modest improvements. However, some countries have declined to include them in public healthcare systems due to high costs. In the UK, a decision on public funding remains under review.

The authors conclude that future research should focus on alternative approaches to treating Alzheimer’s disease.

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